Zebrafish as a suitable model for studying the mode of action and harmfulness of organophosphate pesticides

The aim of the present work was to investigate response zebrafish effects widely-used organophosphates roundup and chlorpyrifos putative effectiveness chlorella in terms decreasing pesticides toxicity. Studied organophosphate pesticide ecologically relevant concentrations, both individually a mixture, evoked prominent suppression catalase total antioxidant capacity liver Danio rerio which were consistent with higher levels lipid peroxidation, protein carbonylation, DNA strand break. Also, provoked endocrine disorders registered as induction vitellogenin depletion triiodothyronine well neurotoxicity appeared inhibition acetylcholinesterase after individual action or activation combined action. rate apoptosis observed by caspase 3 activity decreased, but different manner depends on exposure. potency toxicity followed order: > + (due some kind antagonistic between binary mixture). Based results CART analysis triiodothyronine, TBARS determined most significant indices for discrimination studied groups. introduction Chlorella vulgaris amount about 100 thousand cells L -1 into environment did not show bioremediation effect harmful , does exclude positive impact algae functioning ecosystem whole requires further comprehensive research.